Use of schizophrenia and bipolar disorder polygenic risk scores to identify psychotic disorders.

ABSTRACT:

Background

There is increasing evidence for shared genetic susceptibility between schizophrenia and bipolar disorder. Although genetic variants only convey subtle increases in risk individually, their combination into a polygenic risk score constitutes a strong disease predictor.AimsTo investigate whether schizophrenia and bipolar disorder polygenic risk scores can distinguish people with broadly defined psychosis and their unaffected relatives from controls.

Method

Using the latest Psychiatric Genomics Consortium data, we calculated schizophrenia and bipolar disorder polygenic risk scores for 1168 people with psychosis, 552 unaffected relatives and 1472 controls.

Results

Patients with broadly defined psychosis had dramatic increases in schizophrenia and bipolar polyg

SUBMITTER: Calafato MS 

PROVIDER: S-EPMC6130805 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature