Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type.

ABSTRACT: We describe convergent evidence from transcriptomics, morphology, and physiology for a specialized GABAergic neuron subtype in human cortex. Using unbiased single-nucleus RNA sequencing, we identify ten GABAergic interneuron subtypes with combinatorial gene signatures in human cortical layer 1 and characterize a group of human interneurons with anatomical features never described in rodents, having large 'rosehip'-like axonal boutons and compact arborization. These rosehip cells show an immunohistochemical profile (GAD1⁺CCK⁺, CNR1^-SST^-CALB2^-PVALB^-) matching a single transcriptomically defined cell type whose specific molecular marker signature is not seen in mouse cortex. Rosehip cells in layer 1 make homotypic gap junctions

SUBMITTER: Boldog E 

PROVIDER: S-EPMC6130849 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature