A new model to predict major bleeding in patients with atrial fibrillation using warfarin or direct oral anticoagulants.

ABSTRACT:

Background

No scores presently exist to predict bleeding in atrial fibrillation (AF) populations using direct oral anticoagulants (DOACs). We used data from two independent healthcare claims databases to develop and validate a predictive model of major bleeding in a contemporary AF population.

Methods

Patients with non-valvular AF initiating oral anticoagulation were identified in the MarketScan databases from 2007-2014. Using Cox regression models in 1000 bootstrapped samples, we developed a model that selected variables predicting major bleeding in the first year after anticoagulant initiation. The final model was validated in patients with non-valvular AF in the Optum Clinformatics database in the period 2009-2015. The discriminative ability of existing bleeding scores we

SUBMITTER: Claxton JS 

PROVIDER: S-EPMC6130859 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature