Influence of Cobalt Ions on Collagen Gel Formation and Their Interaction with Osteoblasts.

ABSTRACT: Metals on metal implants have long been used in arthroplasties because of their robustness and low dislocation rate. Several relatively low-corrosion metals have been used in arthroplasty, including 316L stainless steel, titanium, and cobalt-chromium-molybdenum alloy. Debris from these implants, however, has been found to cause inflammatory responses leading to unexpected failure rates approaching 10% 7 years surgery. Safety assessment of these materials traditionally relies on the use of simple two-dimensional assays, where cells are grown on the surface of the material over a relatively short time frame. It is now well-known that the composition and stiffness of the extracellular matrix (ECM) have a critical effect on cell function. In this work, we have evaluated how cobalt ions influen

SUBMITTER: McCarthy EM 

PROVIDER: S-EPMC6130901 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature