Development and application of a multiplex assay for the simultaneous measurement of antibody responses elicited by common childhood vaccines.

ABSTRACT: Because vaccine co-administration can affect elicited immune responses, it is important to evaluate new vaccines in the context of pre-existing vaccination schedules. This is particularly necessary for new pediatric vaccines, as the World Health Organization's infant immunization program already schedules several vaccines to be administered during the first months of life. To facilitate the assessment of inter-vaccine interference, we developed a pediatric vaccine multiplex assay (PVMA) to simultaneously measure antibodies against vaccines commonly administered to infants, including hepatitis B, Haemophilus influenzae type B, diphtheria, tetanus, pertussis, rubella, and respiratory syncytial virus (RSV). Comparison of antibody concentrations determined by enzyme-linked immunosorbent assays

SUBMITTER: Itell HL 

PROVIDER: S-EPMC6130906 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature