Peripubertal serum dioxin concentrations and subsequent sperm methylome profiles of young Russian adults.

ABSTRACT:

Background

The association of exposure to endocrine disrupting chemicals in the peripubertal period with subsequent sperm DNA methylation is unknown.

Objective

We examined the association of peripubertal serum 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) concentrations with whole-genome bisulfite sequencing (WGBS) of sperm collected in young adulthood.

Methods

The Russian Children's Study is a prospective cohort of 516 boys who were enrolled at 8-9 years of age and provided semen samples at 18-19 years of age. WGBS of sperm was conducted to identify differentially methylated regions (DMR) between highest (n = 4) and lowest (n = 4) peripubertal TCDD groups.

Results

We found 52 DMRs that distinguished lowest and highest peripubertal serum TCDD concentrations. One o

SUBMITTER: Pilsner JR 

PROVIDER: S-EPMC6130911 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature