Induction and transcriptional regulation of the co-inhibitory gene module in T cells.

ABSTRACT: The expression of co-inhibitory receptors, such as CTLA-4 and PD-1, on effector T cells is a key mechanism for ensuring immune homeostasis. Dysregulated expression of co-inhibitory receptors on CD4⁺ T cells promotes autoimmunity, whereas sustained overexpression on CD8⁺ T cells promotes T cell dysfunction or exhaustion, leading to impaired ability to clear chronic viral infections and diseases such as cancer^1,2. Here, using RNA and protein expression profiling at single-cell resolution in mouse cells, we identify a module of co-inhibitory receptors that includes not only several known co-inhibitory receptors (PD-1, TIM-3, LAG-3 and TIGIT) but also many new surface receptors. We functionally validated two new co-inhibitory receptors, activated protein C rece

SUBMITTER: Chihara N 

PROVIDER: S-EPMC6130914 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature