Transcription factor-7-like 2 (<i>TCF7L2</i>) gene acts downstream of the <i>Lkb1</i>/<i>Stk11</i> kinase to control mTOR signaling, β cell growth, and insulin secretion.

ABSTRACT: Variants in the transcription factor-7-like 2 (TCF7L2/TCF4) gene, involved in Wnt signaling, are associated with type 2 diabetes. Loss of Tcf7l2 selectively from the β cell in mice has previously been shown to cause glucose intolerance and to lower β cell mass. Deletion of the tumor suppressor liver kinase B1 (LKB1/STK11) leads to β cell hyperplasia and enhanced glucose-stimulated insulin secretion, providing a convenient genetic model for increased β cell growth and function. The aim of this study was to explore the possibility that Tcf7l2 may be required for the effects of Lkb1 deletion on insulin secretion in the mouse β cell. Mice bearing floxed Lkb1 and/or Tcf7l2 alleles were bred with knockin mice bearing Cre recombinase inserte

SUBMITTER: Nguyen-Tu MS 

PROVIDER: S-EPMC6130960 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature