Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli.

ABSTRACT: There is urgent need to develop novel treatment strategies to reduce antimicrobial resistance. Collateral sensitivity (CS), where resistance to one antimicrobial increases susceptibility to other drugs, might enable selection against resistance during treatment. However, the success of this approach would depend on the conservation of CS networks across genetically diverse bacterial strains. Here, we examine CS conservation across diverse Escherichia coli strains isolated from urinary tract infections. We determine collateral susceptibilities of mutants resistant to relevant antimicrobials against 16 antibiotics. Multivariate statistical analyses show that resistance mechanisms, in particular efflux-related mutations, as well as the relative fitness of resistant strains, are principal cont

SUBMITTER: Podnecky NL 

PROVIDER: S-EPMC6131505 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature