Enhancer reprogramming in mammalian genomes.

ABSTRACT:

Background

Transcription factor binding site (TFBS) loss, gain, and reshuffling within the sequence of a regulatory element could alter the function of that regulatory element. Some of the changes will be detrimental to the fitness of the species and will result in gradual removal from a population, while other changes would be either beneficial or just a part of genetic drift and end up being fixed in a population. This "reprogramming" of regulatory elements results in modification of the gene regulatory landscape during evolution.

Results

We identified reprogrammed enhancers (RPEs) by comparing the distribution of tissue-specific enhancers in the human and mouse genomes. We observed that around 30% of mammalian enhancers have been reprogrammed after the human-mouse speciat

SUBMITTER: Flores MA 

PROVIDER: S-EPMC6131754 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature