The human microglial HMC3 cell line: where do we stand? A systematic literature review.

ABSTRACT: Microglia, unique myeloid cells residing in the brain parenchyma, represent the first line of immune defense within the central nervous system. In addition to their immune functions, microglial cells play an important role in other cerebral processes, including the regulation of synaptic architecture and neurogenesis. Chronic microglial activation is regarded as detrimental, and it is considered a pathogenic mechanism common to several neurological disorders. Microglial activation and function have been extensively studied in rodent experimental models, whereas the characterization of human cells has been limited due to the restricted availability of primary sources of human microglia. To overcome this problem, human immortalized microglial cell lines have been developed. The human microgl

SUBMITTER: Dello Russo C 

PROVIDER: S-EPMC6131758 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature