4-Phenyl-1,3-thiazole-2-amines as scaffolds for new antileishmanial agents.

ABSTRACT:

Background

There is still a need for new alternatives in pharmacological therapy for neglected diseases, as the drugs available show high toxicity and parenteral administration. That is the case for the treatment of leishmaniasis, particularly to the cutaneous clinical form of the disease. In this study, we present the synthesis and biological screening of eight 4-phenyl-1,3-thiazol-2-amines assayed against Leishmania amazonensis. Herein we propose that these compounds are good starting points for the search of new antileishmanial drugs by demonstrating some of the structural aspects which could interfere with the observed activity, as well as suggesting potential macromolecular targets.

Methods

The compounds were easily synthesized by the methodology of Hantzsch and

SUBMITTER: Rodrigues CA 

PROVIDER: S-EPMC6131760 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature