Allergy diagnosis from symptoms to molecules, or from molecules to symptoms: a comparative clinical study.

ABSTRACT:

Background

Classical allergy diagnostic workup "from symptoms to molecules" comprises 1) clinical investigation, 2) skin prick- and IgE- testing, and recently, 3) molecular allergy testing. We aimed to examine the diagnostic fidelity of the alternative approach "from molecules to symptoms", which was recently suggested in the EAACI Molecular Allergology User's Guide, in a retrospective clinical study.

Methods

Records from 202 patients with clinically suspected allergic sensitizations were extracted from files at two sites applying either the "ISAC-first" workup with IgE-testing by immuno-solid phase allergen chip ISAC112 followed by selected skin prick tests (SPT) or the "SPT-first" starting with SPT followed by the microarray test.

Results

In the ISAC-first procedure

SUBMITTER: Mothes-Luksch N 

PROVIDER: S-EPMC6131881 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature