Membrane expression of thymidine kinase 1 and potential clinical relevance in lung, breast, and colorectal malignancies.

ABSTRACT:

Background

Lung, breast, and colorectal malignancies are the leading cause of cancer-related deaths in the world causing over 2.8 million cancer-related deaths yearly. Despite efforts to improve prevention methods, early detection, and treatments, survival rates for advanced stage lung, breast, and colon cancer remain low, indicating a critical need to identify cancer-specific biomarkers for early detection and treatment. Thymidine kinase 1 (TK1) is a nucleotide salvage pathway enzyme involved in cellular proliferation and considered an important tumor proliferation biomarker in the serum. In this study, we further characterized TK1's potential as a tumor biomarker and immunotherapeutic target and clinical relevance.

Methods

We assessed TK1 surface localization by flow cytom

SUBMITTER: Weagel EG 

PROVIDER: S-EPMC6131957 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature