Biological Age, Not Chronological Age, Is Associated with Late-Life Depression.

ABSTRACT:

Background

The pathophysiology of late-life depression (LLD) is complex and heterogeneous, with age-related processes implicated in its pathogenesis. This study examined the cross-sectional and longitudinal association between depressive symptoms and a baseline multibiomarker algorithm of biological age (BA) that aggregates indicators of inflammatory, metabolic, cardiovascular, lung, liver, and kidney functioning.

Method

Data were analyzed from 2,776 men and women from the prospective observational Health Aging and Body Composition Study, who had both evaluable chronological age (CA) and BA. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale.

Results

A covariate-adjusted regression model showed that BA (B = 0.03, p =

SUBMITTER: Brown PJ 

PROVIDER: S-EPMC6132120 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature