Antidepressant Use and Cognitive Outcomes in Very Old Women.

ABSTRACT:

Background

Antidepressant use is very common in the elderly, but the effects of antidepressants on cognition in the elderly are controversial with some studies suggesting harm and others protection. We aimed to investigate the association between different antidepressant use and change in cognition and risk of mild cognitive impairment (MCI) or dementia in very old women.

Methods

We examined 1,234 community-dwelling women (mean age 83.2 years) from the Study of Osteoporotic Fractures. Baseline antidepressant use was reported and verified by medication containers, and medications were coded with computerized dictionary. Cognitive status (normal, MCI, or dementia) was adjudicated by an expert clinical panel 5 years later. Change in a short-form Mini-Mental State Examination an

SUBMITTER: Leng Y 

PROVIDER: S-EPMC6132122 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature