Prolonged hematopoietic and myeloid cellular response in patients after an acute coronary syndrome measured with ¹⁸F-DPA-714 PET/CT.

ABSTRACT:

Purpose

An acute coronary syndrome (ACS) is characterized by a multi-level inflammatory response, comprising activation of bone marrow and spleen accompanied by augmented release of leukocytes into the circulation. The duration of this response after an ACS remains unclear. Here, we assessed the effect of an ACS on the multi-level inflammatory response in patients both acutely and after 3 months.

Methods

We performed ¹⁸F-DPA-714 PET/CT acutely and 3 months post-ACS in eight patients and eight matched healthy controls. DPA-714, a PET tracer binding the TSPO receptor and highly expressed in myeloid cells, was used to assess hematopoietic activity. We also characterized circulating monocytes and hematopoietic stem and progenitor cells (HSPCs) by flow cytometry in 20

SUBMITTER: Verweij SL 

PROVIDER: S-EPMC6132543 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature