Multifunctional Proteins: Involvement in Human Diseases and Targets of Current Drugs.

ABSTRACT: Multifunctionality or multitasking is the capability of some proteins to execute two or more biochemical functions. The objective of this work is to explore the relationship between multifunctional proteins, human diseases and drug targeting. The analysis of the proportion of multitasking proteins from the MultitaskProtDB-II database shows that 78% of the proteins analyzed are involved in human diseases. This percentage is much higher than the 17.9% found in human proteins in general. A similar analysis using drug target databases shows that 48% of these analyzed human multitasking proteins are targets of current drugs, while only 9.8% of the human proteins present in UniProt are specified as drug targets. In almost 50% of these proteins, both the canonical and moonlighting functions are r

SUBMITTER: Franco-Serrano L 

PROVIDER: S-EPMC6132618 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature