Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data.

ABSTRACT:

Purpose

The soluble receptor for advanced glycation end-products (sRAGE) is a marker of lung epithelial injury and alveolar fluid clearance (AFC), with promising values for assessing prognosis and lung injury severity in acute respiratory distress syndrome (ARDS). Because AFC is impaired in most patients with ARDS and is associated with higher mortality, we hypothesized that baseline plasma sRAGE would predict mortality, independently of two key mediators of ventilator-induced lung injury.

Methods

We conducted a meta-analysis of individual data from 746 patients enrolled in eight prospective randomized and observational studies in which plasma sRAGE was measured in ARDS articles published through March 2016. The primary outcome was 90-day mortality. Using multivariate and me

SUBMITTER: Jabaudon M 

PROVIDER: S-EPMC6132684 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature