Optic radiations are thinner and show signs of iron deposition in patients with long-standing remitting-relapsing multiple sclerosis: an enhanced T₂^*-weighted angiography imaging study.

ABSTRACT:

Objective

This study aimed to investigate iron deposition and thickness and signal changes in optic radiation (OR) by enhanced T₂^*-weighted angiography imaging (ESWAN) in patients with relapsing-remitting multiple sclerosis (RRMS) with unilateral and bilateral lesions or no lesions.

Methods

Fifty-one RRMS patients (42 patients with a disease duration [DD] ≥ 2 years [group Mor], nine patients with a DD < 2 years [group Les]) and 51 healthy controls (group Con) underwent conventional magnetic resonance imaging (MRI) and ESWAN at 3.0 T. The mean phase value (MPV) of the OR was measured on the phase image, and thickness and signal changes of the OR were observed on the magnitude image.

Results

The average MPVs for the OR were 1,981.55 ± 7.75 in group

SUBMITTER: Zeng C 

PROVIDER: S-EPMC6132724 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature