Relationships between MRI fat distributions and sleep apnea and obesity hypoventilation syndrome in very obese patients.

ABSTRACT:

Purpose

Obesity is associated with both obstructive sleep apnea (OSA) and obesity hypoventilation. Differences in adipose tissue distribution are thought to underlie the development of both OSA and hypoventilation. We explored the relationships between the distribution of upper airway, neck, chest, abdominal and muscle fat in very obese individuals.

Methods

We conducted a cross-sectional cohort study of individuals presenting to a tertiary sleep clinic or for assessment for bariatric surgery. Individuals underwent magnetic resonance (MR) imaging of their upper airway, neck, chest, abdomen and thighs; respiratory polygraphy; 1 week of autotitrating CPAP; and morning arterial blood gas to determine carbon dioxide partial pressure and base excess.

Results

Fifty-three ind

SUBMITTER: Turnbull CD 

PROVIDER: S-EPMC6133118 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature