Genome-wide association study of coronary artery disease among individuals with diabetes: the UK Biobank.

ABSTRACT:

Aims/hypothesis

Coronary artery disease (CAD) is a common complication among individuals with diabetes. A better understanding of the genetic background of CAD in this population has the potential to suggest novel molecular targets for screening, risk assessment and drug development.

Methods

We performed a genome-wide association study of CAD in 15,666 unrelated individuals (3,968 CAD cases and 11,698 controls) of white British ancestry with diabetes at inclusion in the UK Biobank study. Our results were compared with results from participants without diabetes.

Results

We found genome-wide significant evidence for association with CAD at the previously well-established LPA locus (lead variant: rs74617384; OR 1.38 [95% CI 1.26, 1.51], p = 3.2 × 10^-12) and at

SUBMITTER: Fall T 

PROVIDER: S-EPMC6133153 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature