STIM1 deficiency is linked to Alzheimer's disease and triggers cell death in SH-SY5Y cells by upregulation of L-type voltage-operated Ca²⁺ entry.

ABSTRACT: STIM1 is an endoplasmic reticulum protein with a role in Ca²⁺ mobilization and signaling. As a sensor of intraluminal Ca²⁺ levels, STIM1 modulates plasma membrane Ca²⁺ channels to regulate Ca²⁺ entry. In neuroblastoma SH-SY5Y cells and in familial Alzheimer's disease patient skin fibroblasts, STIM1 is cleaved at the transmembrane domain by the presenilin-1-associated γ-secretase, leading to dysregulation of Ca²⁺ homeostasis. In this report, we investigated expression levels of STIM1 in brain tissues (medium frontal gyrus) of pathologically confirmed Alzheimer's disease patients, and observed that STIM1 protein expression level decreased with the progression of neurodegeneration. To study the role of STIM1 in neurodegeneration, a strate

SUBMITTER: Pascual-Caro C 

PROVIDER: S-EPMC6133163 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature