Synthesis of water-degradable silica nanoparticles from carbamate-containing bridged silsesquioxane precursor.

ABSTRACT: Silica nanoparticles (SNPs) are attractive for applications for the delivery of drugs and as imaging agents due to their ease of synthesis and scale up, robust structure, and controllable size and composition. Degradability is one important factor that limits biomedical applications of SNPs. With this in mind, we designed, prepared and characterized novel hydrolysable organosilica nanoparticles (ICPTES-Sorbitol SNPs). These particles were prepared by co-condensation of tetraethoxysilane with a bridged sorbitol-based silsesquioxane precursor containing carbamate linkages. The non-porous spherical ICPTES-Sorbitol SNPs became porous after they were placed in an aqueous environment as a result of the hydrolysis of carbamate bonds and were completely degraded upon prolonged exposure to water. T

SUBMITTER: Gao Z 

PROVIDER: S-EPMC6133298 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature