Ontology highlight
ABSTRACT:
SUBMITTER: Bernardes N
PROVIDER: S-EPMC6133334 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Bernardes Nuno N Garizo Ana Rita AR Pinto Sandra N SN Caniço Bernardo B Perdigão Catarina C Fernandes Fábio F Fialho Arsenio M AM
Cell cycle (Georgetown, Tex.) 20180804 13
Membrane lipid rafts are highly ordered microdomains and essential components of plasma membranes. In this work, we demonstrate that azurin uptake by cancer cells is, in part, mediated by caveolin-1 and GM-1, lipid rafts' markers. This recognition is mediated by a surface exposed hydrophobic core displayed by azurin since the substitution of a phenylalanine residue in position 114 facing the hydrophobic cavity by alanine impacts such interactions, debilitating the uptake of azurin by cancer cell ...[more]