Ontology highlight
ABSTRACT: Abbreviations
TPP+: Triphenylphosphonium cation; ROS: Reactive oxygen species; mtROS: Mitochondrial reactive oxygen species; NAC: N-acetyl-L-cysteine; DCFH-DA: Dichlorodihydrofluorescein diacetate; APC: Anaphase promoting complex; ABPs: Actin-binding proteins; DMEM: Dulbecco's modified Eagle media; SDS: sodium dodecyl sulfate; HEPES: 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid.
SUBMITTER: Titova E
PROVIDER: S-EPMC6133338 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Titova Ekaterina E Shagieva Galina G Ivanova Olga O Domnina Lidiya L Domninskaya Maria M Strelkova Olga O Khromova Natalya N Kopnin Pavel P Chernyak Boris B Skulachev Vladimir V Dugina Vera V
Cell cycle (Georgetown, Tex.) 20180731 14
Mitochondria are important regulators of tumour growth and progression due to their specific role in cancer metabolism and modulation of apoptotic pathways. In this paper we describe that mitochondria-targeted antioxidant SkQ1 designed as a conjugate of decyl-triphenylphosphonium cation (TPP<sup>+</sup>) with plastoquinone, suppressed the growth of fibrosarcoma HT1080 and rhabdomyosarcoma RD tumour cells in culture and tumour growth of RD in xenograft nude mouse model. Under the same conditions, ...[more]