Allergic inflammatory memory in human respiratory epithelial progenitor cells.

ABSTRACT: Barrier tissue dysfunction is a fundamental feature of chronic human inflammatory diseases¹. Specialized subsets of epithelial cells-including secretory and ciliated cells-differentiate from basal stem cells to collectively protect the upper airway^2-4. Allergic inflammation can develop from persistent activation⁵ of type 2 immunity⁶ in the upper airway, resulting in chronic rhinosinusitis, which ranges in severity from rhinitis to severe nasal polyps⁷. Basal cell hyperplasia is a hallmark of severe disease^7-9, but it is not known how these progenitor cells^2,10,11 contribute to clinical presentation and barrier tissue dysfunction in humans. Here we profile primary human surgical chronic rhinosinusitis samples (18,0

SUBMITTER: Ordovas-Montanes J 

PROVIDER: S-EPMC6133715 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature