Zinc uptake promotes myoblast differentiation via Zip7 transporter and activation of Akt signalling transduction pathway.

ABSTRACT: Myogenic regeneration occurs through a chain of events beginning with the output of satellite cells from quiescent state, formation of competent myoblasts and later fusion and differentiation into myofibres. Traditionally, growth factors are used to stimulate muscle regeneration but this involves serious off-target effects, including alterations in cell homeostasis and cancer. In this work, we have studied the use of zinc to trigger myogenic differentiation. We show that zinc promotes myoblast proliferation, differentiation and maturation of myofibres. We demonstrate that this process occurs through the PI3K/Akt pathway, via zinc stimulation of transporter Zip7. Depletion of zinc transporter Zip7 by RNA interference shows reduction of both PI3K/Akt signalling and a significant reduction of

SUBMITTER: Mnatsakanyan H 

PROVIDER: S-EPMC6133932 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature