Trans-abdominal in vivo placental vessel occlusion using High Intensity Focused Ultrasound.

ABSTRACT: Pre-clinically, High Intensity Focused Ultrasound (HIFU) has been shown to safely and effectively occlude placental blood vessels in the acute setting, when applied through the uterus. However, further development of the technique to overcome the technical challenges of targeting and occluding blood vessels through intact skin remains essential to translation into human studies. So too does the assessment of fetal wellbeing following this procedure, and demonstration of the persistence of vascular occlusion. At 115 ± 10 d gestational age (term~147 days) 12 pregnant sheep were exposed to HIFU (n = 6), or to a sham (n = 6) therapy through intact abdominal skin (1.66 MHz, 5 s duration, in situ I_SPTA 1.3-4.4 kW.cm^-2). Treatment success was defined as undetectable colour D

SUBMITTER: Shaw CJ 

PROVIDER: S-EPMC6134117 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature