Quillaja brasiliensis saponin-based nanoparticulate adjuvants are capable of triggering early immune responses.

ABSTRACT: Commercially available saponins are extracted from Quillaja saponaria barks, being Quil A^® the most widely used. Nanoparticulate immunostimulating complexes (ISCOMs or ISCOMATRIX) formulated with these, are able to stimulate strong humoral and cellular immune responses. Recently, we formulated novel ISCOMs replacing QuilA^® by QB-90 (IQB-90), a Quillaja brasiliensis leaf-extracted saponin fraction, and reported that IQB-90 improved antigen uptake, and induced systemic and mucosal antibody production, and T-cell responses. However, its mechanism of action remains unclear. In this study we provide a deeper insight into the immune stimulatory properties of QB-90 and ISCOMATRIX-like based on this fraction (IMXQB-90). We show herein that, when used as a viral vaccine adjuva

SUBMITTER: Cibulski SP 

PROVIDER: S-EPMC6134118 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature