Investigation of hindbrain activity during active locomotion reveals inhibitory neurons involved in sensorimotor processing.

ABSTRACT: Locomotion in vertebrates relies on motor circuits in the spinal cord receiving inputs from the hindbrain to execute motor commands while dynamically integrating proprioceptive sensory feedback. The spatial organization of the neuronal networks driving locomotion in the hindbrain and role of inhibition has not been extensively investigated. Here, we mapped neuronal activity with single-cell resolution in the hindbrain of restrained transgenic Tg(HuC:GCaMP5G) zebrafish larvae swimming in response to whole-field visual motion. We combined large-scale population calcium imaging in the hindbrain with simultaneous high-speed recording of the moving tail in animals where specific markers label glycinergic inhibitory neurons. We identified cells whose activity preferentially correlates with the v

SUBMITTER: Severi KE 

PROVIDER: S-EPMC6134141 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature