Clinical Relevance of Genomic Changes in Recurrent Pediatric Solid Tumors.

ABSTRACT:

Purpose

Relapsed/refractory pediatric cancers show poor prognosis; however, their genomic patterns remain unknown. To investigate the genetic mechanisms of tumor relapse and therapy resistance, we characterized genomic alterations in diagnostic and relapsed lesions in patients with relapsed/refractory pediatric solid tumors using targeted deep sequencing.

Patients and methods

A targeted sequencing panel covering the exons of 381 cancer genes was used to characterize 19 paired diagnostic and relapsed samples from patients with relapsed/refractory pediatric solid tumors.

Results

The mean coverage for all samples was 930.6× (SD = 213.8). Among the 381 genes, 173 single nucleotide variations (SNVs)/insertion-deletions (InDels), 100 copy number alterations, and 1 structura

SUBMITTER: Lee B 

PROVIDER: S-EPMC6134157 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature