Analysis of stromal mucin in oral epithelial dysplasia & oral squamous cell carcinoma- A histochemical study.

ABSTRACT:

Background

Mucins are glycoproteins that act as a selective molecular barrier and its alterations usually accompany the carcinogenesis.

Aim

To evaluate the transition of mucins in the grades of oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC) using histochemical stains.

Materials & method

A total of 66 samples of variable grades of OED and OSCC and each section was stained with PAS, Alcian blue- PAS (AB-PAS) and Aldehyde fuschin - Alcian blue (AF-AB). Mucins pattern and intensity were examined at 5 randomly selected fields on 10x magnification.

Results

1. PAS stain - Predominantly OED and OSCC showed a diffuse pattern with a gradual decrease in intensity in OED and overall a weak intensity in OSCC. 2. AB-PAS stain - Neutral mucins showed

SUBMITTER: Sahni A 

PROVIDER: S-EPMC6134164 | biostudies-literature | 2019 Jan-Mar

REPOSITORIES: biostudies-literature