Ontology highlight
ABSTRACT:
SUBMITTER: Kooreman NG
PROVIDER: S-EPMC6134179 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Cell stem cell 20180215 4
Cancer cells and embryonic tissues share a number of cellular and molecular properties, suggesting that induced pluripotent stem cells (iPSCs) may be harnessed to elicit anti-tumor responses in cancer vaccines. RNA sequencing revealed that human and murine iPSCs express tumor-associated antigens, and we show here a proof of principle for using irradiated iPSCs in autologous anti-tumor vaccines. In a prophylactic setting, iPSC vaccines prevent tumor growth in syngeneic murine breast cancer, mesot ...[more]