Autologous iPSC-Based Vaccines Elicit Anti-tumor Responses In Vivo.

ABSTRACT: Cancer cells and embryonic tissues share a number of cellular and molecular properties, suggesting that induced pluripotent stem cells (iPSCs) may be harnessed to elicit anti-tumor responses in cancer vaccines. RNA sequencing revealed that human and murine iPSCs express tumor-associated antigens, and we show here a proof of principle for using irradiated iPSCs in autologous anti-tumor vaccines. In a prophylactic setting, iPSC vaccines prevent tumor growth in syngeneic murine breast cancer, mesothelioma, and melanoma models. As an adjuvant, the iPSC vaccine inhibited melanoma recurrence at the resection site and reduced metastatic tumor load, which was associated with fewer Th17 cells and increased CD11b⁺GR1^hi myeloid cells. Adoptive transfer of T cells isolated from v

SUBMITTER: Kooreman NG 

PROVIDER: S-EPMC6134179 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature