Inhibition of NF-κB in astrocytes is sufficient to delay neurodegeneration induced by proteotoxicity in neurons.

ABSTRACT:

Background

Most neurodegenerative diseases associated with protein aggregation are hallmarked by activation of astrocytes. However, how astrocytes are activated or which signaling pathways in astrocytes contribute to pathogenesis is not clear. One long-standing question is whether the responses in astrocytes are due to stress or damage in astrocytes themselves, or because of astrocytic responses to cellular stress or damage in neurons. Here, we examine responses in astrocytes induced by expression of disease-associated, aggregation-prone proteins in other cells. We also examine the consequences of these responses in astrocytes in a model for neurodegeneration.

Methods

We first examined a role for intracellular astrocytic responses in a Drosophila model for Spinocerebellar at

SUBMITTER: Li YX 

PROVIDER: S-EPMC6134576 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature