Assessment of acute, 14-day, and 13-week repeated oral dose toxicity of Tiglium seed extract in rats.

ABSTRACT:

Background

Seed of mature Croton tiglium Linne, also known as Tiglium seed (TS), has been widely used as a natural product due to its several health beneficial properties including anti-tumor and antifungal activities. Despite its ethnomedicinal beneficial properties, toxicological information regarding TS extract, especially its long-term toxicity, is currently limited. Therefore, the objective of the present study was to evaluate acute and subchronic toxicity of TS extract in rats after oral administration following test guidelines of the Organization for Economic Cooperation and Development (OECD).

Methods

Toxicological properties of TS extract were evaluated by toxicity assays to determine its single-dose acute toxicity (125, 250, 500, 1000, or 2000 mg/kg), 14-day repeat

SUBMITTER: Yun JW 

PROVIDER: S-EPMC6134578 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature