Association of different iron deficiency cutoffs with adverse outcomes in chronic kidney disease.

ABSTRACT:

Background

Iron deficiency is highly prevalent in chronic kidney disease (CKD) patients. In clinical practice, iron deficiency is defined based on a combination of two commonly used markers, ferritin and transferrin saturation (TSAT). However, no consensus has been reached which cutoffs of these parameters should be applied to define iron deficiency. Hence, we aimed to assess prospectively which cutoffs of ferritin and TSAT performed optimally for outcomes in CKD patients.

Methods

We meticulously analyzed 975 CKD community dwelling patients of the Prevention of Renal and Vascular Endstage Disease prospective study based on an estimated glomerular filtration rate < 60 ml/min/1.73m², albuminuria > 30 mg/24 h, or albumin-to-creatinine ratio ≥ 30 mg/g. Cox proportiona

SUBMITTER: Eisenga MF 

PROVIDER: S-EPMC6134584 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature