Potential adverse effects of botanical supplementation in high-fat-fed female mice.

ABSTRACT:

Background

Insulin resistance underlies metabolic syndrome and is associated with excess adiposity and visceral fat accumulation, which is more frequently observed in males than females. However, in young females, the prevalence of metabolic syndrome is rising, mainly driven by accumulation of abdominal visceral fat. The degree to which sex-related differences could influence the development of insulin resistance remains unclear, and studies of potential therapeutic strategies to combat metabolic syndrome using rodent models have focused predominantly on males. We therefore evaluated the effects of two nutritional supplements derived from botanical sources, an extract of Artemisia dracunculus L. (termed PMI5011) and Momordica charantia (commonly known as bitter melon), on female mi

SUBMITTER: Fuller S 

PROVIDER: S-EPMC6134698 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature