Antibiotic therapy for skin and soft tissue infections: a protocol for a systematic review and network meta-analysis.

ABSTRACT:

Background

Skin and soft tissue infections (SSTIs) in hospital and community settings impose a substantial socio-economic burden. Therapeutic uncertainty due to the availability of a wide range of antibiotics and the need for empirical treatment decisions complicate SSTI clinical management. Completion of numerous pairwise meta-analyses to account for this variability in antibiotics is impractical, and many head-to-head comparisons of potential interest are likely not available. In comparing multiple antibiotics simultaneously, this network meta-analysis aims to identify the antibiotic(s) with the greatest value in the treatment of SSTIs, in terms of patient-important outcomes such as efficacy and safety.

Methods

We will conduct a systematic review to identify randomized con

SUBMITTER: Bartoszko JJ 

PROVIDER: S-EPMC6134765 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature