Therapeutic mesopore construction on 2D Nb₂C MXenes for targeted and enhanced chemo-photothermal cancer therapy in NIR-II biowindow.

ABSTRACT: Two-dimensional (2D) MXenes have emerged as a promising planar theranostic nanoplatform for versatile biomedical applications; but their in vivo behavior and performance has been severely influenced and hindered by a lack of necessary surface chemistry for adequate surface engineering. To solve this critical issue, this work employs versatile sol-gel chemistry for the construction of a unique "therapeutic mesopore" layer onto the surface of 2D niobium carbide (Nb₂C) MXene. Methods: The in situ self-assembled mesopore-making agent (cetanecyltrimethylammonium chloride, in this case) was kept within the mesopores for efficient chemotherapy. The abundant surface saline chemistry of mesoporous silica-coated Nb₂C MXene was further adopted for stepwise s

SUBMITTER: Han X 

PROVIDER: S-EPMC6134934 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature