Identifying environmental chemicals as agonists of the androgen receptor by using a quantitative high-throughput screening platform.

ABSTRACT: The androgen receptor (AR, NR3C4) is a nuclear receptor whose main function is acting as a transcription factor regulating gene expression for male sexual development and maintaining accessory sexual organ function. It is also a necessary component of female fertility by affecting the functionality of ovarian follicles and ovulation. Pathological processes involving AR include Kennedy's disease and Klinefelter's syndrome, as well as prostate, ovarian, and testicular cancer. Strict regulation of sex hormone signaling is required for normal reproductive organ development and function. Therefore, testing small molecules for their ability to modulate AR is a first step in identifying potential endocrine disruptors. We screened the Tox21 10K compound library in a quantitative high-throughput fo

SUBMITTER: Lynch C 

PROVIDER: S-EPMC6135100 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature