Administration of mycophenolic acid is not associated with malformations in descendants from kidney transplanted males.

ABSTRACT:

Background

In pregnant women, the use of Mycophenolic acid (MPA) is associated with teratogenicity. Recently, the European Medicines Agency (EMEA) and the Spanish Agency of Medicine and Sanitary Products (AEMPS) warned about the potential teratogenic effects of MPA. These adverse events may occur even in children from males on treatment with MPA. However, evidence of malformations in offsprings of male kidney transplanted patients (KT) exposed to MPA is limited. Thus, the present study aimed to evaluate the incidence of offspring malformations in children of renal transplanted males under MPA.

Materials and methods

We conducted a retrospective study in which we evaluated the incidence of malformations in descendants from male recipients that were exposed or not to MPA before

SUBMITTER: Lopez-Lopez I 

PROVIDER: S-EPMC6135357 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature