Maternal Allopurinol Prevents Cardiac Dysfunction in Adult Male Offspring Programmed by Chronic Hypoxia During Pregnancy.

ABSTRACT: Integrating functional and molecular levels, we investigated the effects of maternal treatment with a xanthine oxidase inhibitor on the programming of cardiac dysfunction in adult offspring using an established rat model of hypoxic pregnancy. Female Wistar rats were divided into normoxic or hypoxic (13% O₂) pregnancy±maternal allopurinol treatment (30 mg kg^-1 d^-1). At 4 months, hearts were isolated from 1 male per litter per outcome variable to determine cardiac function and responses to ischemia-reperfusion in a Langendorff preparation. Sympathetic dominance, perfusate CK (creatine kinase) and LDH (lactate dehydrogenase) and the cardiac protein expression of the β₁-adrenergic receptor, the M₂ Ach receptor (muscarinic type-2 acetylchol

SUBMITTER: Niu Y 

PROVIDER: S-EPMC6135482 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature