Identification of MMP28 as a biomarker for the differential diagnosis of idiopathic pulmonary fibrosis.

ABSTRACT:

Background and objective

Idiopathic Pulmonary Fibrosis (IPF) is a progressive disease of unknown etiology. The diagnosis is based on the identification of a pattern of usual interstitial pneumonia either by high resolution computed tomography and/or histology. However, a similar pattern can be observed in other fibrotic lung disorders, and precise diagnosis remains challenging. Studies on biomarkers contributing to the differential diagnosis are scanty, and still in an exploratory phase. Our aim was to evaluate matrix metalloproteinase (MMP)-28, which has been implicated in abnormal wound healing, as a biomarker for distinguishing IPF from fibrotic non-IPF patients.

Methods

The cell localization of MMP28 in lungs was examined by immunohistochemistry and its serum concentrati

SUBMITTER: Maldonado M 

PROVIDER: S-EPMC6135486 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature