Proton-pump Inhibitor Use and Fracture Risk: An Updated Systematic Review and Meta-analysis.

ABSTRACT:

Background

This study's objective was to evaluate the association between proton-pump inhibitor (PPI) use and bone fracture incidence and bone mineral density (BMD) by meta-analyzing the estimates reported by epidemiological and cohort studies.

Methods

Data were acquired from studies identified after a literature search in electronic databases. Odds ratios (ORs), hazard ratios (HRs), and risk ratios (RRs) between PPI use and bone fracture incidence were pooled under the random effects model, and meta-analysis of standardized mean differences between PPI users and controls in cross-sectional values and BMD changes was conducted.

Results

Thirty-three studies fulfilled the eligibility criteria. These studies provided data from 2,714,502 individuals with a mean age of 66.

SUBMITTER: Nassar Y 

PROVIDER: S-EPMC6135649 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature