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Potential lymphangiogenesis therapies: Learning from current antiangiogenesis therapies-A review.


ABSTRACT: In recent years, lymphangiogenesis, the process of lymphatic vessel formation from existing lymph vessels, has been demonstrated to have a significant role in diverse pathologies, including cancer metastasis, organ graft rejection, and lymphedema. Our understanding of the mechanisms of lymphangiogenesis has advanced on the heels of studies demonstrating vascular endothelial growth factor C as a central pro-lymphangiogenic regulator and others identifying multiple lymphatic endothelial biomarkers. Despite these breakthroughs and a growing appreciation of the signaling events that govern the lymphangiogenic process, there are no FDA-approved drugs that target lymphangiogenesis. In this review, we reflect on the lessons available from the development of antiangiogenic therapies (26 FDA-approved drugs to date), review current lymphangiogenesis research including nanotechnology in therapeutic drug delivery and imaging, and discuss molecules in the lymphangiogenic pathway that are promising therapeutic targets.

SUBMITTER: Yamakawa M 

PROVIDER: S-EPMC6135718 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Potential lymphangiogenesis therapies: Learning from current antiangiogenesis therapies-A review.

Yamakawa Michael M   Doh Susan J SJ   Santosa Samuel M SM   Montana Mario M   Qin Ellen C EC   Kong Hyunjoon H   Han Kyu-Yeon KY   Yu Charles C   Rosenblatt Mark I MI   Kazlauskas Andrius A   Chang Jin-Hong JH   Azar Dimitri T DT  

Medicinal research reviews 20180312 6


In recent years, lymphangiogenesis, the process of lymphatic vessel formation from existing lymph vessels, has been demonstrated to have a significant role in diverse pathologies, including cancer metastasis, organ graft rejection, and lymphedema. Our understanding of the mechanisms of lymphangiogenesis has advanced on the heels of studies demonstrating vascular endothelial growth factor C as a central pro-lymphangiogenic regulator and others identifying multiple lymphatic endothelial biomarkers  ...[more]

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