Genome-wide association meta-analysis of coronary artery disease and periodontitis reveals a novel shared risk locus.

ABSTRACT: Evidence for a shared genetic basis of association between coronary artery disease (CAD) and periodontitis (PD) exists. To explore the joint genetic basis, we performed a GWAS meta-analysis. In the discovery stage, we used a German aggressive periodontitis sample (AgP-Ger; 680 cases vs 3,973 controls) and the CARDIoGRAMplusC4D CAD meta-analysis dataset (60,801 cases vs 123,504 controls). Two SNPs at the known CAD risk loci ADAMTS7 (rs11634042) and VAMP8 (rs1561198) passed the pre-assigned selection criteria (P_AgP-Ger < 0.05; P_CAD < 5 × 10^-8; concordant effect direction) and were replicated in an independent GWAS meta-analysis dataset of PD (4,415 cases vs 5,935 controls). SNP rs1561198 showed significant association (PD[Replication]: P = 0.008 OR = 1.09, 95

SUBMITTER: Munz M 

PROVIDER: S-EPMC6135769 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature