Calprotectin protects against experimental colonic inflammation in mice.

ABSTRACT:

Background and purpose

Calprotectin is a heterodimer composed of two myeloid-related proteins, S100A8 and S100A9, that is abundant in neutrophils and monocytes/macrophages. Faecal levels of calprotectin are used routinely to monitor inflammatory bowel disease activity.

Experimental approach

We aimed to assess the role of calprotectin in intestinal inflammation, using the dextran sulfate sodium model of colitis in mice. Calprotectin was administered (50 or 100 μg·day^-1 ) by the intrarectal or by i.p. injection (50 μg·day^-1 only). The condition of the mice was characterized by morphological and biochemical methods.

Key results

Intrarectal calprotectin protected significantly against colitis, as shown by lower levels of macroscopic and microscopic d

SUBMITTER: Aranda CJ 

PROVIDER: S-EPMC6135788 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature