Doxorubicin induces an extensive transcriptional and metabolic rewiring in yeast cells.

ABSTRACT: Doxorubicin is one of the most effective chemotherapy drugs used against solid tumors in the treatment of several cancer types. Two different mechanisms, (i) intercalation of doxorubicin into DNA and inhibition of topoisomerase II leading to changes in chromatin structure, (ii) generation of free radicals and oxidative damage to biomolecules, have been proposed to explain the mode of action of this drug in cancer cells. A genome-wide integrative systems biology approach used in the present study to investigate the long-term effect of doxorubicin in Saccharomyces cerevisiae cells indicated the up-regulation of genes involved in response to oxidative stress as well as in Rad53 checkpoint sensing and signaling pathway. Modular analysis of the active sub-network has also revealed the induction

SUBMITTER: Taymaz-Nikerel H 

PROVIDER: S-EPMC6135803 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature