Genetic assessment of inbred chicken lines indicates genomic signatures of resistance to Marek's disease.

ABSTRACT:

Background

Marek's disease (MD) is a highly contagious pathogenic and oncogenic disease primarily affecting chickens. However, the mechanisms of genetic resistance for MD are complex and not fully understood. MD-resistant line 6₃ and MD-susceptible line 7₂ are two highly inbred progenitor lines of White Leghorn. Recombinant Congenic Strains (RCS) were developed from these two lines, which show varied susceptibility to MD.

Results

We investigated genetic structure and genomic signatures across the genome, including the line 6₃ and line 7₂, six RCSs, and two reciprocally crossed flocks between the lines 6₃ and 7₂ (F1 6₃ × 7₂ and F1 7₂ × 6₃) using Affymetrix® Axiom® HD

SUBMITTER: Xu L 

PROVIDER: S-EPMC6136188 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature